Curated Information
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Curated Information Page
PubMed Id: 16917065 
Park KS, Mohapatra DP, Misonou H, Trimmer JS (2006) Graded regulation of the Kv2.1 potassium channel by variable phosphorylation. Science 313, 976-9 16917065
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S15-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S15‑p, Kv2.1 (mouse): S15‑p, Kv2.1 (rat): S15‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionomycin decrease
FK520 ionomycin inhibit treatment-induced decrease
Downstream Regulation
 Effect of modification (function):  activity, inhibited

S457-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S457‑p, Kv2.1 (mouse): S457‑p, Kv2.1 (rat): S457‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionomycin decrease
FK520 ionomycin inhibit treatment-induced decrease
Downstream Regulation
 Effect of modification (function):  activity, inhibited

S484-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S484‑p, Kv2.1 (mouse): S484‑p, Kv2.1 (rat): S484‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionomycin no change compared to control
Downstream Regulation
 Effect of modification (function):  activity, inhibited

S496-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S496‑p, Kv2.1 (mouse): S496‑p, Kv2.1 (rat): S496‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

S503-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S503‑p, Kv2.1 (mouse): S503‑p, Kv2.1 (rat): S503‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human

S520-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S520‑p, Kv2.1 (mouse): S520‑p, Kv2.1 (rat): S520‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, rat

S541-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S541‑p, Kv2.1 (mouse): S541‑p, Kv2.1 (rat): S541‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionomycin decrease
FK520 ionomycin inhibit treatment-induced decrease
Downstream Regulation
 Effect of modification (function):  activity, inhibited

S567-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S567‑p, Kv2.1 (mouse): S567‑p, Kv2.1 (rat): S567‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionomycin decrease
FK520 ionomycin inhibit treatment-induced decrease
Downstream Regulation
 Effect of modification (function):  activity, inhibited

S590-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S590‑p, Kv2.1 (mouse): S590‑p, Kv2.1 (rat): S590‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

S607-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S607‑p, Kv2.1 (mouse): S607‑p, Kv2.1 (rat): S607‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionomycin decrease
FK520 ionomycin inhibit treatment-induced decrease
Downstream Regulation
 Effect of modification (function):  activity, inhibited

S655-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S656‑p, Kv2.1 (mouse): S655‑p, Kv2.1 (rat): S655‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionomycin decrease
FK520 ionomycin inhibit treatment-induced decrease

S719-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S720‑p, Kv2.1 (mouse): S719‑p, Kv2.1 (rat): S719‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionomycin decrease
FK520 ionomycin inhibit treatment-induced decrease
Downstream Regulation
 Effect of modification (function):  activity, inhibited

S771-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S772‑p, Kv2.1 (mouse): S771‑p, Kv2.1 (rat): S771‑p
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionomycin no change compared to control
Downstream Regulation
 Effect of modification (function):  activity, inhibited

S799-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S800‑p, Kv2.1 (mouse): S799‑p, Kv2.1 (rat): S799‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

S804-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): S805‑p, Kv2.1 (mouse): S804‑p, Kv2.1 (rat): S804‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionomycin no change compared to control

T836-p - Kv2.1 (rat)
Orthologous residues
Kv2.1 (human): I837‑p, Kv2.1 (mouse): T836‑p, Kv2.1 (rat): T836‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human


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