Curated Information
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PubMed Id: 19545277 
Gillardon F (2009) Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration? J Neurochem 110, 1514-22 19545277
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S494-p - Tau (mouse)
Orthologous residues
Tau (human): S519‑p, Tau iso2 (human): S144‑p, Tau iso3 (human): S108‑p, Tau iso5 (human): S202‑p, Tau iso6 (human): S144‑p, Tau iso7 (human): S173‑p, Tau iso8 (human): S202‑p, Tau (mouse): S494‑p, Tau iso3 (mouse): S191‑p, Tau iso7 (mouse): S151‑p, Tau (rat): S513‑p, Tau (cow): S209‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LRRK2 (mouse) decrease knock-out mice

T497-p - Tau (mouse)
Orthologous residues
Tau (human): T522‑p, Tau iso2 (human): T147‑p, Tau iso3 (human): T111‑p, Tau iso5 (human): T205‑p, Tau iso6 (human): T147‑p, Tau iso7 (human): T176‑p, Tau iso8 (human): T205‑p, Tau (mouse): T497‑p, Tau iso3 (mouse): T194‑p, Tau iso7 (mouse): T154‑p, Tau (rat): T516‑p, Tau (cow): T212‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LRRK2 (mouse) decrease knock-out mice

T107-p - TUBB (cow)
Orthologous residues
TUBB (human): T107‑p, TUBB (mouse): T107‑p, TUBB (rat): T107‑p, TUBB (cow): T107‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE LRRK2 (human)

T107-p - TUBB2B (cow)
Orthologous residues
TUBB2B (human): T107‑p, TUBB2B (mouse): T107‑p, TUBB2B (rat): T107‑p, TUBB2B (cow): T107‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE LRRK2 (human)

T107-p - TUBB2C (cow)
Orthologous residues
TUBB2C (human): T107‑p, TUBB2C (mouse): T107‑p, TUBB2C (rat): T107‑p, TUBB2C (cow): T107‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE LRRK2 (human)

T107-p - TUBB3 (cow)
Orthologous residues
TUBB3 (human): T107‑p, TUBB3 (mouse): T107‑p, TUBB3 (rat): T107‑p, TUBB3 (cow): T107‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE LRRK2 (human)

T107-p - TUBB4 (cow)
Orthologous residues
TUBB4 (human): T107‑p, TUBB4 (mouse): T107‑p, TUBB4 (rat): T107‑p, TUBB4 (cow): T107‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE LRRK2 (human)


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