Curated Information
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Curated Information Page
PubMed Id: 11404460 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Lin HK, Yeh S, Kang HY, Chang C (2001) Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proc Natl Acad Sci U S A 98, 7200-5 11404460
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S213-p - AR (human)
Orthologous residues
AR (human): S213‑p, AR (mouse): T208‑p, AR (rat): T211‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  COS (fibroblast), DU 145 (prostate cell), PC3 (prostate cell)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) transfection of constitutively active enzyme, transfection of inactive enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LY294002 decrease
IGF-1 increase
LY294002 IGF-1 inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  activity, inhibited
 Effect of modification (process):  apoptosis, inhibited

S791-p - AR (human)
Orthologous residues
AR (human): S791‑p, AR (mouse): S771‑p, AR (rat): S774‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  COS (fibroblast), DU 145 (prostate cell), PC3 (prostate cell)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) transfection of constitutively active enzyme, transfection of inactive enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LY294002 decrease
IGF-1 increase
LY294002 IGF-1 inhibit treatment-induced increase


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