Curated Information
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Curated Information Page
PubMed Id: 17046825 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Lu TJ, et al. (2006) Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST. J Biol Chem 281, 38405-17 17046825
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T190-p - MST3 (human) ▲
Orthologous residues
MST3 (human): T190‑p, MST3 iso2 (human): T178‑p, MST3 (mouse): T178‑p, MST3 (rat): T231‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast), MDCK (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  dog, monkey
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE MST3 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE MST3 (human) mutation in upstream enzyme recognition motif, electrophoretic mobility shift
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Effect of modification (process):  cell motility, altered

Y31-p - PXN iso2 (human) ▲
Orthologous residues
PXN (human): Y31‑p, PXN iso2 (human): Y31‑p, PXN iso3 (human): Y31‑p, PXN iso6 (human): Y38‑p, PXN (mouse): Y31‑p, PXN iso2 (mouse): Y31‑p, PXN (rat): Y31‑p, PXN (chicken): Y31‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MDCK (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  dog, human
Downstream Regulation
 Effect of modification (function):  activation
 Effect of modification (process):  cell motility, altered

Y118-p - PXN iso2 (human) ▲
Orthologous residues
PXN (human): Y118‑p, PXN iso2 (human): Y118‑p, PXN iso3 (human): Y118‑p, PXN iso6 (human): Y125‑p, PXN (mouse): Y118‑p, PXN iso2 (mouse): Y118‑p, PXN (rat): Y118‑p, PXN (chicken): Y118‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), MDCK (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  dog, human
Upstream Regulation
 Comments:  PTP-PEST phosphatase, evidence: by phospho-antibody and inhibition of enzyme
Downstream Regulation
 Effect of modification (function):  activation
 Effect of modification (process):  cell motility, altered


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