Curated Information
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Curated Information Page
PubMed Id: 17166829 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Sanchez M, Sauvé K, Picard N, Tremblay A (2007) The hormonal response of estrogen receptor beta is decreased by the phosphatidylinositol 3-kinase/Akt pathway via a phosphorylation-dependent release of CREB-binding protein. J Biol Chem 282, 4830-40 17166829
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S473-p - Akt1 (human)
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HER3 (human), HER2 (human) increase sight increase
heregulin augment treatment-induced increase
HER3 (human), HER2 (human) augment treatment-induced increase constitutively active HER2
heregulin ER-beta (mouse) increase
heregulin ER-alpha (mouse) increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  S236 phosphorylation modulates intranuclear localization in Akt activated cells.

T1872-p - CBP (mouse)
Orthologous residues
CBP (human): T1871‑p, CBP (mouse): T1872‑p, CBP (rat): T1872‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) mutation in upstream enzyme recognition motif, modification site within consensus motif, activation of upstream enzyme
Downstream Regulation
 Effect of modification (process):  transcription, induced

S236-p - ER-beta (mouse)
Orthologous residues
ER‑beta (human): D236‑p, ER‑beta (mouse): S236‑p, ER‑beta (rat): S236‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) mutation in upstream enzyme recognition motif, modification site within consensus motif, activation of upstream enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  S236 phosphorylation modulates intranuclear localization in Akt activated cells.


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