Curated Information

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Curated Information Page

PubMed Id: 19524539

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Yannay-Cohen N, et al. (2009) LysRS serves as a key signaling molecule in the immune response by regulating gene expression. Mol Cell 34, 603-11 19524539

S207-p - KARS (human)

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Orthologous residues

KARS (human): S207‑p, KARS iso2 (human): S235‑p, KARS (mouse): S205‑p, KARS (rat): S236‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, western blotting

Relevant cell lines - cell types - tissues: RBL-2H3 (basophil)

Species studied: rat

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	ERK1 (human)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
U0126				decrease
PD98059				decrease

Downstream Regulation

Effect of modification (function): enzymatic activity, induced, intracellular localization

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