Curated Information
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Curated Information Page
PubMed Id: 19478092 
Murakami T, Felinski EA, Antonetti DA (2009) Occludin Phosphorylation and Ubiquitination Regulate Tight Junction Trafficking and Vascular Endothelial Growth Factor-induced Permeability. J Biol Chem 284, 21036-46 19478092
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S490-p - occludin (human)
Orthologous residues
occludin (human): S490‑p, occludin iso2 (human): S436‑p, occludin iso3 (human): , occludin (mouse): S489‑p, occludin (rat): S491‑p, occludin (chicken): S472‑p, occludin (cow): S417‑p
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  BREC (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  cow
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
VEGF increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation, protein degradation, ubiquitination
 Effect of modification (process):  endocytosis, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Hrs (human) Induces co-immunoprecipitation
epsin 1 (human) Induces co-immunoprecipitation
EPS15 (human) Induces co-immunoprecipitation
ITCH (human) Induces co-immunoprecipitation
 Comments:  alters tight junctions and promotes vascular permeability

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