Curated Information
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Curated Information Page
PubMed Id: 17164333 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Skaggs BJ, et al. (2006) Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants. Proc Natl Acad Sci U S A 103, 19466-71 17164333
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

Y115-p - Abl (human)
Orthologous residues
Abl (human): Y115‑p, Abl iso2 (human): Y134‑p, Abl (mouse): Y115‑p, Abl iso2 (mouse): Y134‑p, Abl (rat): Y115‑p, Abl iso2 (rat): Y134‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315A mutation

Y253-p - Abl (human)
Orthologous residues
Abl (human): Y253‑p, Abl iso2 (human): Y272‑p, Abl (mouse): Y253‑p, Abl iso2 (mouse): Y272‑p, Abl (rat): Y253‑p, Abl iso2 (rat): Y272‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315A mutation

Y257-p - Abl (human)
Orthologous residues
Abl (human): Y257‑p, Abl iso2 (human): Y276‑p, Abl (mouse): Y257‑p, Abl iso2 (mouse): Y276‑p, Abl (rat): Y257‑p, Abl iso2 (rat): Y276‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315I mutation
Associated Diseases
Diseases: Alterations: Comments:
leukemia increased elevated in drug resistant leukemias with T315I mutations in Abl, and is associated with increased oncogenicity

Y393-p - Abl (human)
Orthologous residues
Abl (human): Y393‑p, Abl iso2 (human): Y412‑p, Abl (mouse): Y393‑p, Abl iso2 (mouse): Y412‑p, Abl (rat): Y393‑p, Abl iso2 (rat): Y412‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315A mutation

Y413-p - Abl (human)
Orthologous residues
Abl (human): Y413‑p, Abl iso2 (human): Y432‑p, Abl (mouse): Y413‑p, Abl iso2 (mouse): Y432‑p, Abl (rat): Y413‑p, Abl iso2 (rat): Y432‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl Y253F mutation

Y570-p - BCAP (mouse)
Orthologous residues
BCAP (human): Y570‑p, BCAP (mouse): Y570‑p, BCAP (rat): , BCAP (chicken): Y567‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl E255V mutation

Y643-p - Bcr (mouse)
Orthologous residues
Bcr (human): Y644‑p, Bcr (mouse): Y643‑p, Bcr (rat): Y643‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315A mutation

Y30-p - CCT-theta (mouse)
Orthologous residues
CCT‑theta (human): Y30‑p, CCT‑theta (mouse): Y30‑p, CCT‑theta (rat): Y30‑p, CCT‑theta (cow): Y30‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl M315T mutation

Y184-p - CSK (mouse)
Orthologous residues
CSK (human): Y184‑p, CSK (mouse): Y184‑p, CSK (rat): Y184‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl E255K mutation

Y718-p - DDB1 (mouse)
Orthologous residues
DDB1 (human): Y718‑p, DDB1 (mouse): Y718‑p, DDB1 (rat): Y718‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315I mutation

Y879-p - eIF3C (mouse)
Orthologous residues
eIF3C (human): Y881‑p, eIF3C (mouse): Y879‑p, eIF3C (rat): Y879‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315A mutation

Y25-p - ENO1 (mouse)
Orthologous residues
ENO1 (human): F25‑p, ENO1 (mouse): Y25‑p, ENO1 (rat): Y25‑p, ENO1 (chicken): Y25‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl E255K mutation

Y44-p - ENO1 (mouse)
Orthologous residues
ENO1 (human): Y44‑p, ENO1 (mouse): Y44‑p, ENO1 (rat): Y44‑p, ENO1 (chicken): Y44‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl E255K mutation

Y52-p - H4 (mouse)
Orthologous residues
H4 (human): Y52‑p, H4 (mouse): Y52‑p, H4 (rat): Y52‑p, H4 (pig): Y52‑p, H4 (cow): Y52‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl M315T mutation

Y484-p - HSP90B (mouse)
Orthologous residues
HSP90B (human): Y484‑p, HSP90B (mouse): Y484‑p, HSP90B (rat): Y484‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl Y253F mutation

Y251-p - LIM (mouse)
Orthologous residues
LIM (human): Y251‑p, LIM iso2 (human): Y148‑p, LIM iso10 (human): Y251‑p, LIM (mouse): Y251‑p, LIM iso3 (mouse): Y153‑p, LIM (rat): Y251‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315A mutation

Y467-p - PIK3R1 (mouse)
Orthologous residues
PIK3R1 (human): Y467‑p, PIK3R1 (mouse): Y467‑p, PIK3R1 (rat): Y467‑p, PIK3R1 (cow): Y467‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y367-p - PPM1B (mouse)
Orthologous residues
PPM1B (human): Y367‑p, PPM1B iso2 (human): Y367‑p, PPM1B (mouse): Y367‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl M315T mutation

Y868-p - SHIP (mouse)
Orthologous residues
SHIP (human): Y865‑p, SHIP (mouse): Y868‑p, SHIP (rat): Y867‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl E255V mutation

Y468-p - VARS (mouse)
Orthologous residues
VARS (human): Y469‑p, VARS (mouse): Y468‑p, VARS (rat): Y469‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y80-p - VDAC1 (mouse)
Orthologous residues
VDAC1 (human): Y67‑p, VDAC1 (mouse): Y80‑p, VDAC1 (rat): Y67‑p, VDAC1 (pig): Y67‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl M315T mutation


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