Curated Information
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Curated Information Page
PubMed Id: 17164333 
Skaggs BJ, et al. (2006) Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants. Proc Natl Acad Sci U S A 103, 19466-71 17164333
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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Y115-p - Abl (human)
Orthologous residues
Abl (human): Y115‑p, Abl iso2 (human): Y134‑p, Abl (mouse): Y115‑p, Abl iso2 (mouse): Y134‑p, Abl (rat): Y115‑p, Abl iso2 (rat): Y134‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315A mutation

Y253-p - Abl (human)
Orthologous residues
Abl (human): Y253‑p, Abl iso2 (human): Y272‑p, Abl (mouse): Y253‑p, Abl iso2 (mouse): Y272‑p, Abl (rat): Y253‑p, Abl iso2 (rat): Y272‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315A mutation

Y257-p - Abl (human)
Orthologous residues
Abl (human): Y257‑p, Abl iso2 (human): Y276‑p, Abl (mouse): Y257‑p, Abl iso2 (mouse): Y276‑p, Abl (rat): Y257‑p, Abl iso2 (rat): Y276‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315I mutation
Associated Diseases
Diseases: Alterations: Comments:
leukemia increased elevated in drug resistant leukemias with T315I mutations in Abl, and is associated with increased oncogenicity

Y393-p - Abl (human)
Orthologous residues
Abl (human): Y393‑p, Abl iso2 (human): Y412‑p, Abl (mouse): Y393‑p, Abl iso2 (mouse): Y412‑p, Abl (rat): Y393‑p, Abl iso2 (rat): Y412‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315A mutation

Y413-p - Abl (human)
Orthologous residues
Abl (human): Y413‑p, Abl iso2 (human): Y432‑p, Abl (mouse): Y413‑p, Abl iso2 (mouse): Y432‑p, Abl (rat): Y413‑p, Abl iso2 (rat): Y432‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl Y253F mutation

Y570-p - BCAP (mouse)
Orthologous residues
BCAP (human): Y570‑p, BCAP (mouse): Y570‑p, BCAP (rat): , BCAP (chicken): Y567‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl E255V mutation

Y643-p - Bcr (mouse)
Orthologous residues
Bcr (human): Y644‑p, Bcr iso2 (human): Y644‑p, Bcr (mouse): Y643‑p, Bcr (rat): Y643‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315A mutation

Y30-p - CCT-theta (mouse)
Orthologous residues
CCT‑theta (human): Y30‑p, CCT‑theta (mouse): Y30‑p, CCT‑theta (rat): Y30‑p, CCT‑theta (cow): Y30‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl M315T mutation

Y184-p - CSK (mouse)
Orthologous residues
CSK (human): Y184‑p, CSK (mouse): Y184‑p, CSK (rat): Y184‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl E255K mutation

Y718-p - DDB1 (mouse)
Orthologous residues
DDB1 (human): Y718‑p, DDB1 (mouse): Y718‑p, DDB1 (rat): Y718‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315I mutation

Y879-p - EIF3C (mouse)
Orthologous residues
EIF3C (human): Y881‑p, EIF3C (mouse): Y879‑p, EIF3C (rat): Y879‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315A mutation

Y25-p - ENO1 (mouse)
Orthologous residues
ENO1 (human): F25‑p, ENO1 (mouse): Y25‑p, ENO1 (rat): Y25‑p, ENO1 (chicken): Y25‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl E255K mutation

Y44-p - ENO1 (mouse)
Orthologous residues
ENO1 (human): Y44‑p, ENO1 (mouse): Y44‑p, ENO1 (rat): Y44‑p, ENO1 (chicken): Y44‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl E255K mutation

Y52-p - H4 (mouse)
Orthologous residues
H4 (human): Y52‑p, H4 (mouse): Y52‑p, H4 (rat): Y52‑p, H4 (pig): Y52‑p, H4 (cow): Y52‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl M315T mutation

Y484-p - HSP90B (mouse)
Orthologous residues
HSP90B (human): Y484‑p, HSP90B (mouse): Y484‑p, HSP90B (rat): Y484‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl Y253F mutation

Y251-p - LIM (mouse)
Orthologous residues
LIM (human): Y251‑p, LIM iso2 (human): Y148‑p, LIM iso10 (human): Y251‑p, LIM (mouse): Y251‑p, LIM iso3 (mouse): Y153‑p, LIM (rat): Y251‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl T315A mutation

Y467-p - PIK3R1 (mouse)
Orthologous residues
PIK3R1 (human): Y467‑p, PIK3R1 iso2 (human): Y197‑p, PIK3R1 (mouse): Y467‑p, PIK3R1 (rat): Y467‑p, PIK3R1 (cow): Y467‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y367-p - PPM1B (mouse)
Orthologous residues
PPM1B (human): Y367‑p, PPM1B iso2 (human): Y367‑p, PPM1B (mouse): Y367‑p, PPM1B iso6 (mouse): Y367‑p, PPM1B (rat): Y367‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl M315T mutation

Y868-p - SHIP (mouse)
Orthologous residues
SHIP (human): Y865‑p, SHIP iso2 (human): Y864‑p, SHIP (mouse): Y868‑p, SHIP (rat): Y867‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl E255V mutation

Y468-p - VARS (mouse)
Orthologous residues
VARS (human): Y469‑p, VARS (mouse): Y468‑p, VARS (rat): Y469‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y80-p - VDAC1 (mouse)
Orthologous residues
VDAC1 (human): Y67‑p, VDAC1 (mouse): Y80‑p, VDAC1 (rat): Y67‑p, VDAC1 (pig): Y67‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor') [Abl (human)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl (human) increase Abl M315T mutation


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