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Orthologous residues
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|
CTNNB1 (human): S552‑p, CTNNB1 (mouse): S552‑p, CTNNB1 (rat): S552‑p
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Characterization
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|
Methods used to characterize site in vivo:
immunoprecipitation, phospho-antibody
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|
Disease tissue studied:
Cowden disease
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|
Relevant cell lines - cell types - tissues:
intestine
|
|
Cellular systems studied:
tissue
|
|
Species studied:
mouse
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|
Enzymes shown to modify site in vitro:
|
|
|
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Upstream Regulation
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|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
|
|
PTEN (mouse)
|
|
decrease
|
increased in PTEN -/- mouse; associated with increased intestinal polyposis
|
|
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Downstream Regulation
|
|
Effect of modification (function):
intracellular localization
|
|
Associated Diseases
|
|
Diseases:
|
Alterations:
|
Comments:
|
|
Cowden disease
|
hyperphosphorylation
|
observed in PTEN mouse mutant
|
|
