Curated Information
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PubMed Id: 17124499 
Han SJ, et al. (2006) Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation. EMBO J 25, 5716-25 17124499
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S290-p - PDE3A (mouse)
Orthologous residues
PDE3A (human): S292‑p, PDE3A (mouse): S290‑p, PDE3A (rat): S290‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  MA-10 (testicular), oocyte [CPEB (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  frog, human, mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) transfection of inactive enzyme, transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Comments:  required for insulin-dependent Xenopus oocyte maturation;activated during oocytes maturation in mouse treated with hCG

S291-p - PDE3A (mouse)
Orthologous residues
PDE3A (human): S293‑p, PDE3A (mouse): S291‑p, PDE3A (rat): S291‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  MA-10 (testicular), oocyte [CPEB (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  frog, human, mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) transfection of inactive enzyme, transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Comments:  required for insulin-dependent Xenopus oocyte maturation;activated during oocytes maturation in mouse treated with hCG

S292-p - PDE3A (mouse)
Orthologous residues
PDE3A (human): S294‑p, PDE3A (mouse): S292‑p, PDE3A (rat): S292‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  MA-10 (testicular), oocyte [CPEB (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  frog, human, mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) transfection of inactive enzyme, transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Comments:  required for insulin-dependent Xenopus oocyte maturation;activated during oocytes maturation in mouse treated with hCG


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