Curated Information
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PubMed Id: 12556484 
Yan X, et al. (2003) Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle. Mol Cell Biol 23, 1239-50 12556484
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S198-p - NDEL1 (human)
Orthologous residues
NDEL1 (human): S198‑p, NDEL1 (mouse): S198‑p, NDEL1 (rat): S198‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nocodazole increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PAFAH1B1 (human) Induces co-immunoprecipitation

T219-p - NDEL1 (human)
Orthologous residues
NDEL1 (human): T219‑p, NDEL1 (mouse): T219‑p, NDEL1 (rat): T219‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)
KINASE CDK1 (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nocodazole increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PAFAH1B1 (human) Induces co-immunoprecipitation

S231-p - NDEL1 (human)
Orthologous residues
NDEL1 (human): S231‑p, NDEL1 (mouse): S231‑p, NDEL1 (rat): S231‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nocodazole increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PAFAH1B1 (human) Induces co-immunoprecipitation

S242-p - NDEL1 (human)
Orthologous residues
NDEL1 (human): S242‑p, NDEL1 (mouse): S242‑p, NDEL1 (rat): S242‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK1 (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nocodazole increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PAFAH1B1 (human) Induces co-immunoprecipitation

T245-p - NDEL1 (human)
Orthologous residues
NDEL1 (human): T245‑p, NDEL1 (mouse): T245‑p, NDEL1 (rat): T245‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)
KINASE CDK1 (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nocodazole increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PAFAH1B1 (human) Induces co-immunoprecipitation


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