Brondello JM, Pouysségur J, McKenzie FR (1999) Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science 286, 2514-7 10617468

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S359-p - DUSP1 (human) ▲

Modsite: SALSYLQsPITTsPS SwissProt Entrez-Gene Orthologous residues DUSP1 (human): S359‑p, DUSP1 (mouse): S359‑p, DUSP1 (rat): S359‑p Characterization Methods used to characterize site in vivo:  [32P] ATP in vitro, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial), Dede (fibroblast) Cellular systems studied:  cell lines Species studied:  hamster, human Enzymes shown to modify site in vitro:  Type Enzyme KINASE ERK1 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE ERK1 (human) modification site within consensus motif Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes serum increase estradiol increase PD98059 estradiol inhibit treatment-induced increase Downstream Regulation Effect of modification (function):  protein stabilization

S364-p - DUSP1 (human) ▲

Modsite: LQsPITTsPSC____ SwissProt Entrez-Gene Orthologous residues DUSP1 (human): S364‑p, DUSP1 (mouse): S364‑p, DUSP1 (rat): S364‑p Characterization Methods used to characterize site in vivo:  [32P] ATP in vitro, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial), Dede (fibroblast) Cellular systems studied:  cell lines Species studied:  hamster, human Enzymes shown to modify site in vitro:  Type Enzyme KINASE ERK1 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE ERK1 (human) modification site within consensus motif Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes serum increase estradiol increase PD98059 estradiol inhibit treatment-induced increase Downstream Regulation Effect of modification (function):  protein stabilization