Curated Information

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Curated Information Page

PubMed Id: 17003105

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Schmitt E, et al. (2006) CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage. J Cell Sci 119, 4269-75 17003105

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S230-p - Cdc25B (human)

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Orthologous residues

Cdc25B (human): S230‑p, Cdc25B iso2 (human): S216‑p, Cdc25B iso3 (human): S189‑p, Cdc25B (mouse): S229‑p, Cdc25B (rat): S227‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: HeLa (cervical), U2OS (bone cell) [GR (human)]

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	Chk1 (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	Chk1 (human)	pharmacological inhibitor of upstream enzyme, antisense inhibition of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
UCN-01				decrease

Downstream Regulation

Effect of modification (function): enzymatic activity, inhibited

Comments: inhibits mitosis-inducing activity of CDC25B

S563-p - Cdc25B (human)

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