Curated Information
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Curated Information Page
PubMed Id: 7706316 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Drewes G, et al. (1995) Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262. J Biol Chem 270, 7679-88 7706316
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S262-p - Tau iso8 (human)
Orthologous residues
Tau (human): S579‑p, Tau iso2 (human): S204‑p, Tau iso3 (human): S168‑p, Tau iso5 (human): S262‑p, Tau iso6 (human): S204‑p, Tau iso7 (human): S233‑p, Tau iso8 (human): S262‑p, Tau (mouse): S554‑p, Tau iso3 (mouse): S251‑p, Tau iso7 (mouse): S211‑p, Tau (rat): S573‑p, Tau (cow): S269‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE MARK1 (human)
 Comments:  p110mark from pig brain
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
TUBA1A (cow) Disrupts in vitro
TUBB (cow) Disrupts in vitro

S293-p - Tau iso8 (human)
Orthologous residues
Tau (human): S610‑p, Tau iso2 (human): , Tau iso3 (human): , Tau iso5 (human): , Tau iso6 (human): S235‑p, Tau iso7 (human): S264‑p, Tau iso8 (human): S293‑p, Tau (mouse): S585‑p, Tau iso3 (mouse): S282‑p, Tau iso7 (mouse): S242‑p, Tau (rat): S604‑p, Tau (cow): S300‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
KINASE PKACA (human)
KINASE MARK1 (human)
 Comments:  p110mark from pig brain

S305-p - Tau iso8 (human)
Orthologous residues
Tau (human): S622‑p, Tau iso2 (human): , Tau iso3 (human): , Tau iso5 (human): , Tau iso6 (human): S247‑p, Tau iso7 (human): S276‑p, Tau iso8 (human): S305‑p, Tau (mouse): S597‑p, Tau iso3 (mouse): S294‑p, Tau iso7 (mouse): S254‑p, Tau (rat): S616‑p, Tau (cow): S312‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
KINASE MARK1 (human)
KINASE PKCA (human)
 Comments:  p110mark from pig brain

S324-p - Tau iso8 (human)
Orthologous residues
Tau (human): S641‑p, Tau iso2 (human): S235‑p, Tau iso3 (human): S199‑p, Tau iso5 (human): S293‑p, Tau iso6 (human): S266‑p, Tau iso7 (human): S295‑p, Tau iso8 (human): S324‑p, Tau (mouse): S616‑p, Tau iso3 (mouse): S313‑p, Tau iso7 (mouse): S273‑p, Tau (rat): S635‑p, Tau (cow): S331‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
KINASE MARK1 (human)
KINASE PKACA (human)
 Comments:  p110mark from pig brain

S356-p - Tau iso8 (human)
Orthologous residues
Tau (human): S673‑p, Tau iso2 (human): S267‑p, Tau iso3 (human): S231‑p, Tau iso5 (human): S325‑p, Tau iso6 (human): S298‑p, Tau iso7 (human): S327‑p, Tau iso8 (human): S356‑p, Tau (mouse): S648‑p, Tau iso3 (mouse): S345‑p, Tau iso7 (mouse): S305‑p, Tau (rat): S667‑p, Tau (cow): S363‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE MARK1 (human)
KINASE PKACA (human)
 Comments:  p110mark from pig brain


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