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Orthologous residues
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DYNLT1 (human): S82‑p, DYNLT1 (mouse): S82‑p, DYNLT1 (rat): S82‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site
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Relevant cell lines - cell types - tissues:
293 (epithelial), MDCK (epithelial)
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Cellular systems studied:
cell lines
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Species studied:
human
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Downstream Regulation
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Effect of modification (function):
molecular association, regulation
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Modification regulates interactions with:
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Interacting molecule
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Interacting domains
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Effect
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Consequences (function)
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Consequences (process)
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Detection assays
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DNCLI1 (human)
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Disrupts
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co-immunoprecipitation, yeast two-hybrid
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rhodopsin (human)
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Induces
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co-immunoprecipitation
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Comments:
S82E and S82A mutants cause relocalization of rhodopsin; S82E mutant TCTEL1 is excluded, while S82A mutant protein is impaired in release, from dynein complexes
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