Curated Information
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Curated Information Page
PubMed Id: 14765123 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Gdalyahu A, et al. (2004) DCX, a new mediator of the JNK pathway. EMBO J 23, 823-32 14765123
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T321-p - Doublecortin iso2 (human)
Orthologous residues
Doublecortin (human): T402‑p, Doublecortin iso2 (human): T321‑p, Doublecortin (mouse): T326‑p, Doublecortin iso3 (mouse): T321‑p, Doublecortin (rat): T326‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain
 Cellular systems studied:  primary cultured cells
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE JNK2 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE JNK2 (rat) transfection of constitutively active enzyme, co-immunoprecipitation, transfection of dominant-negative enzyme, pharmacological inhibitor of upstream enzyme
KINASE JNK1 (rat) transfection of constitutively active enzyme, co-immunoprecipitation, transfection of dominant-negative enzyme, pharmacological inhibitor of upstream enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell motility, altered, cytoskeletal reorganization
 Comments:  affects doublecortin localization to growth cones, neurite outgrowth, and neuronal motility

T331-p - Doublecortin iso2 (human)
Orthologous residues
Doublecortin (human): T412‑p, Doublecortin iso2 (human): T331‑p, Doublecortin (mouse): T336‑p, Doublecortin iso3 (mouse): T331‑p, Doublecortin (rat): T336‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain
 Cellular systems studied:  primary cultured cells
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE JNK2 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE JNK2 (rat) transfection of constitutively active enzyme, co-immunoprecipitation, transfection of dominant-negative enzyme, pharmacological inhibitor of upstream enzyme
KINASE JNK1 (rat) transfection of constitutively active enzyme, co-immunoprecipitation, transfection of dominant-negative enzyme, pharmacological inhibitor of upstream enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell motility, altered, cytoskeletal reorganization
 Comments:  affects doublecortin localization to growth cones, neurite outgrowth, and neuronal motility

S334-p - Doublecortin iso2 (human)
Orthologous residues
Doublecortin (human): S415‑p, Doublecortin iso2 (human): S334‑p, Doublecortin (mouse): S339‑p, Doublecortin iso3 (mouse): S334‑p, Doublecortin (rat): S339‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain
 Cellular systems studied:  primary cultured cells
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE JNK2 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE JNK2 (rat) transfection of constitutively active enzyme, co-immunoprecipitation, transfection of dominant-negative enzyme, pharmacological inhibitor of upstream enzyme
KINASE JNK1 (rat) transfection of constitutively active enzyme, co-immunoprecipitation, transfection of dominant-negative enzyme, pharmacological inhibitor of upstream enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell motility, altered, cytoskeletal reorganization
 Comments:  affects doublecortin localization to growth cones, neurite outgrowth, and neuronal motility


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