Curated Information
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Curated Information Page
PubMed Id: 15580310 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Chang NS, et al. (2005) 17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo. Oncogene 24, 714-23 15580310
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T202-p - ERK1 (human) ▲
Orthologous residues
ERK1 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  breast cancer, breast ductal carcinoma, neuroblastoma, prostate cancer
 Relevant cell lines - cell types - tissues:  breast, COS (fibroblast), DU 145 (prostate cell), MCF-7 (breast cell), MDA-MB-435S (breast cell), MDA-MB231 (breast cell), Mv1Lu (epithelial), prostate, SKNSH (neural crest)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mink, monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
estrogen increase
androsterone increase

Y204-p - ERK1 (human) ▲
Orthologous residues
ERK1 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  breast cancer, breast ductal carcinoma, neuroblastoma, prostate cancer
 Relevant cell lines - cell types - tissues:  breast, COS (fibroblast), DU 145 (prostate cell), MCF-7 (breast cell), MDA-MB-435S (breast cell), MDA-MB231 (breast cell), Mv1Lu (epithelial), prostate, SKNSH (neural crest)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mink, monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
estrogen increase
androsterone increase

T185-p - ERK2 (human) ▲
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  breast cancer, breast ductal carcinoma, neuroblastoma, prostate cancer
 Relevant cell lines - cell types - tissues:  breast, COS (fibroblast), DU 145 (prostate cell), MCF-7 (breast cell), MDA-MB-435S (breast cell), MDA-MB231 (breast cell), Mv1Lu (epithelial), prostate, SKNSH (neural crest)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mink, monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
estrogen increase
androsterone increase

Y187-p - ERK2 (human) ▲
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  breast cancer, breast ductal carcinoma, neuroblastoma, prostate cancer
 Relevant cell lines - cell types - tissues:  breast, COS (fibroblast), DU 145 (prostate cell), MCF-7 (breast cell), MDA-MB-435S (breast cell), MDA-MB231 (breast cell), Mv1Lu (epithelial), prostate, SKNSH (neural crest)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mink, monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
estrogen increase
androsterone increase

S15-p - p53 (human) ▲
Orthologous residues
p53 (human): S15‑p, p53 (mouse): S15‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (monkey): S15‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  breast cancer, breast ductal carcinoma, neuroblastoma, prostate cancer
 Relevant cell lines - cell types - tissues:  breast, COS (fibroblast), DU 145 (prostate cell), MCF-7 (breast cell), MDA-MB-435S (breast cell), MDA-MB231 (breast cell), Mv1Lu (epithelial), prostate, SKNSH (neural crest)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mink, monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
estrogen increase
androsterone no change compared to control

Y33-p - WWOX (human) ▲
Orthologous residues
WWOX (human): Y33‑p, WWOX (mouse): Y33‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  breast cancer, breast ductal carcinoma, neuroblastoma, prostate cancer
 Relevant cell lines - cell types - tissues:  breast, COS (fibroblast), DU 145 (prostate cell), MCF-7 (breast cell), MDA-MB-435S (breast cell), MDA-MB231 (breast cell), Mv1Lu (epithelial), prostate, SKNSH (neural crest)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mink, monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
estrogen increase
androsterone increase
Associated Diseases
Diseases: Alterations: Comments:
prostate cancer increased


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