Curated Information
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Curated Information Page
PubMed Id: 12082086 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Casteel DE, et al. (2002) cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I. J Biol Chem 277, 32003-14 12082086
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

S412-p - GTF2I (human)
Orthologous residues
GTF2I (human): S412‑p, GTF2I iso2 (human): S371‑p, GTF2I (mouse): S412‑p, GTF2I iso8 (mouse): S372‑p, GTF2I (rat): S393‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  BHK (fibroblast), COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster, monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKG1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKG1 (human) pharmacological activator of upstream enzyme, modification site within consensus motif, microscopy-colocalization, co-immunoprecipitation, transfection of wild-type enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
cGMP analog increase
Downstream Regulation
 Effect of modification (process):  transcription, induced

S784-p - GTF2I (human)
Orthologous residues
GTF2I (human): S784‑p, GTF2I iso2 (human): S743‑p, GTF2I (mouse): S784‑p, GTF2I iso8 (mouse): S744‑p, GTF2I (rat): S765‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  BHK (fibroblast), COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster, monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKG1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKG1 (human) pharmacological activator of upstream enzyme, modification site within consensus motif, microscopy-colocalization, co-immunoprecipitation, transfection of wild-type enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
cGMP analog increase
Downstream Regulation
 Effect of modification (process):  transcription, induced


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