Curated Information
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Curated Information Page
PubMed Id: 11063592 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Kang Y, et al. (2000) Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling. Biochemistry 39, 13551-7 11063592
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S236-p - FPR2 (human)
Orthologous residues
FPR2 (human): S236‑p, FPR2 (mouse): S236‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  leukemia
 Relevant cell lines - cell types - tissues:  CHO (fibroblast), HL60 (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  hamster, human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LXA4 increase
Downstream Regulation
 Effect of modification (function):  receptor desensitization, altered
 Comments:  downregulates PLA2 and PLD activation

S237-p - FPR2 (human)
Orthologous residues
FPR2 (human): S237‑p, FPR2 (mouse): S237‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  leukemia
 Relevant cell lines - cell types - tissues:  CHO (fibroblast), HL60 (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  hamster, human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LXA4 increase
Downstream Regulation
 Effect of modification (function):  receptor desensitization, altered
 Comments:  downregulates PLA2 and PLD activation

Y302-p - FPR2 (human)
Orthologous residues
FPR2 (human): Y302‑p, FPR2 (mouse): Y302‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  leukemia
 Relevant cell lines - cell types - tissues:  CHO (fibroblast), HL60 (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  hamster, human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LXA4 increase
Downstream Regulation
 Effect of modification (function):  receptor desensitization, altered
 Comments:  downregulates PLD activation


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