Curated Information
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Curated Information Page
PubMed Id: 10821852 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Emanuelli B, et al. (2000) SOCS-3 is an insulin-induced negative regulator of insulin signaling. J Biol Chem 275, 15985-91 10821852
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Y999-p - InsR (human)
Orthologous residues
InsR (human): Y999‑p, InsR iso2 (human): Y987‑p, InsR (mouse): Y989‑p, InsR (rat): Y1000‑p
Characterization
 Methods used to characterize site in vivo microscopy-colocalization with upstream kinase, western blotting
 Relevant cell lines - cell types - tissues:  3T3-L1 (fibroblast), COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SOCS3 (human) SH2 Induces intracellular localization yeast two-hybrid
 Comments:  Phosphorylation induces colocalization of the insulin receptor with SOCS-3 at cell surface.


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