Curated Information

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PubMed Id: 10821852

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Emanuelli B, et al. (2000) SOCS-3 is an insulin-induced negative regulator of insulin signaling. J Biol Chem 275, 15985-91 10821852

Y999-p - InsR (human)

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Orthologous residues

InsR (human): Y999‑p, InsR iso2 (human): Y987‑p, InsR (mouse): Y989‑p, InsR (rat): Y1000‑p

Characterization

Methods used to characterize site in vivo: microscopy-colocalization with upstream kinase, western blotting

Relevant cell lines - cell types - tissues: 3T3-L1 (fibroblast), COS (fibroblast)

Cellular systems studied: cell lines

Species studied: monkey

Downstream Regulation

Effect of modification (function): molecular association, regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
SOCS3 (human)	SH2	Induces	intracellular localization		yeast two-hybrid

Comments: Phosphorylation induces colocalization of the insulin receptor with SOCS-3 at cell surface.

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