Emanuelli B, et al. (2000) SOCS-3 is an insulin-induced negative regulator of insulin signaling. J Biol Chem 275, 15985-91 10821852

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Y999-p - INSR (human) ▲

Modsite: yASSNPEyLSASDVF SwissProt Entrez-Gene Orthologous residues INSR (human): Y999‑p, INSR iso2 (human): Y987‑p, INSR (mouse): Y989‑p, INSR (rat): Y1000‑p Characterization Methods used to characterize site in vivo:  microscopy-colocalization with upstream kinase, western blotting Relevant cell lines - cell types - tissues:  3T3-L1 (fibroblast), COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays SOCS3 (human) SH2 Induces intracellular localization yeast two-hybrid Comments:  Phosphorylation induces colocalization of the insulin receptor with SOCS-3 at cell surface.