Curated Information
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Curated Information Page
PubMed Id: 10936190 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Iijima K, et al. (2000) Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5. J Neurochem 75, 1085-91 10936190
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T668-p - APP iso4 (human)
Orthologous residues
APP (human): T743‑p, APP iso4 (human): T668‑p, APP iso8 (human): T724‑p, APP (mouse): T743‑p, APP iso2 (mouse): T668‑p, APP (rat): T743‑p, APP iso2 (rat): T668‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK5 (rat)

T668-p - APP iso2 (rat)
Orthologous residues
APP (human): T743‑p, APP iso4 (human): T668‑p, APP iso8 (human): T724‑p, APP (mouse): T743‑p, APP iso2 (mouse): T668‑p, APP (rat): T743‑p, APP iso2 (rat): T668‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, microscopy-colocalization with upstream kinase, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, neuron-'brain, hippocampus'
 Cellular systems studied:  primary cultured cells, tissue
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK5 (rat)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK5 (rat) microscopy-colocalization, antisense inhibition of upstream enzyme
Downstream Regulation
 Comments:  T668 phosphorylated APP is localized to the somaticic plasma membrane and neurites.


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