Curated Information
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Curated Information Page
PubMed Id: 16916597 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Morley S, et al. (2007) Requirement for Akt-mediated survival in cell transformation by the dbl oncogene. Cell Signal 19, 211-8 16916597
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T308-p - Akt1 (mouse)
Orthologous residues
Akt1 (human): T308‑p, Akt1 (mouse): T308‑p, Akt1 (rat): T308‑p, Akt1 (fruit fly): T423‑p, Akt1 (cow): T308‑p
Characterization
 Methods used to characterize site in vivo phosphoamino acid analysis, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
serum increase
MCF2 (human) increase
insulin increase
insulin CDC42 iso1 (human) inhibit treatment-induced increase Cdc42(T17N)
CDC42 iso1 (human) no change compared to control
CDC42 iso1 (human) increase constitutively active
CDC42 iso1 (human) no change compared to control constitutively active mutant
MCF2 (human) increase
wortmannin inhibit treatment-induced increase
RAC1 (human) increase wild-type
RAC1 (human) increase constitutively active
RhoA (human) increase wild-type
RhoA (human) no change compared to control constitutively active

S136-p - BAD (mouse)
Orthologous residues
BAD (human): S99‑p, BAD (mouse): S136‑p, BAD (rat): S137‑p
Characterization
 Methods used to characterize site in vivo phosphoamino acid analysis, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MCF2 (human) increase
serum increase


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