|
Orthologous residues
|
|
caveolin‑1 (human): Y14‑p, caveolin‑1 (mouse): Y14‑p, caveolin‑1 (rat): Y14‑p, caveolin‑1 (dog): Y14‑p, caveolin‑1 (sheep): Y14‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
immunoprecipitation, phospho-antibody
|
|
Relevant cell lines - cell types - tissues:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
mouse
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
Src (mouse)
|
genetic transfer of wild-type enzyme
|
|
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
heat shock
|
|
|
|
no change compared to control
|
|
|
UV
|
|
|
|
increase
|
|
|
H2O2
|
|
|
|
increase
|
|
|
osmotic stress
|
|
|
|
increase
|
|
|
SB203580
|
osmotic stress
|
|
|
inhibit treatment-induced increase
|
|
|
cytochalasin D
|
osmotic stress
|
|
|
augment treatment-induced increase
|
|
|
nocodazole
|
osmotic stress
|
|
|
augment treatment-induced increase
|
|
|
