Curated Information
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Curated Information Page
PubMed Id: 11094059 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Volonté D, Galbiati F, Pestell RG, Lisanti MP (2001) Cellular stress induces the tyrosine phosphorylation of caveolin-1 (Tyr(14)) via activation of p38 mitogen-activated protein kinase and c-Src kinase. Evidence for caveolae, the actin cytoskeleton, and focal adhesions as mechanical sensors of osmotic stress. J Biol Chem 276, 8094-103 11094059
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Y14-p - Caveolin-1 (mouse)
Orthologous residues
Caveolin‑1 (human): Y14‑p, Caveolin‑1 (mouse): Y14‑p, Caveolin‑1 (rat): Y14‑p, Caveolin‑1 (dog): Y14‑p, Caveolin‑1 (sheep): Y14‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (mouse) genetic transfer of wild-type enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat shock no change compared to control
UV increase
H2O2 increase
osmotic stress increase
SB203580 osmotic stress inhibit treatment-induced increase
cytochalasin D osmotic stress augment treatment-induced increase
nocodazole osmotic stress augment treatment-induced increase


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