Curated Information
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Curated Information Page
PubMed Id: 10933394 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Fujimoto M, et al. (2000) CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity 13, 47-57 10933394
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y500-p - CD19 (human) ▲
Orthologous residues
CD19 (human): Y500‑p, CD19 (mouse): Y493‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  B lymphocyte-spleen
 Cellular systems studied:  cell lines, primary cells
 Species studied:  mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Lyn (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Lyn (human) co-immunoprecipitation, genetic knockout/knockin of upstream enzyme
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Lyn (human) Induces enzymatic activity, induced, molecular association, regulation co-immunoprecipitation
PIK3CA (human) Induces molecular association, regulation co-immunoprecipitation
VAV1 (human) Induces enzymatic activity, induced co-immunoprecipitation

Y531-p - CD19 (human) ▲
Orthologous residues
CD19 (human): Y531‑p, CD19 (mouse): Y522‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  B lymphocyte-spleen
 Cellular systems studied:  cell lines, primary cells
 Species studied:  mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Lyn (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Lyn (human) co-immunoprecipitation, genetic knockout/knockin of upstream enzyme
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3CA (human) Induces molecular association, regulation co-immunoprecipitation
Lyn (human) Induces enzymatic activity, induced, molecular association, regulation co-immunoprecipitation
VAV1 (human) Induces enzymatic activity, induced co-immunoprecipitation


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