Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Curated Information Page
PubMed Id: 11598012 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Kang SW, et al. (2001) PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization. EMBO J 20, 5692-702 11598012
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

S180-p - Btk (mouse) ▲
Orthologous residues
Btk (human): S180‑p, Btk (mouse): S180‑p, Btk (rat): S181‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], A20 (B lymphocyte), DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken, mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCB (mouse) transfection of wild-type enzyme
Downstream Regulation
 Effect of modification (function):  inhibition, intracellular localization

Y223-p - Btk (mouse) ▲
Orthologous residues
Btk (human): Y223‑p, Btk (mouse): Y223‑p, Btk (rat): Y224‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], A20 (B lymphocyte), DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken, mouse

Y551-p - Btk (mouse) ▲
Orthologous residues
Btk (human): Y551‑p, Btk (mouse): Y551‑p, Btk (rat): Y552‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], A20 (B lymphocyte), DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken, mouse


Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.