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Orthologous residues
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B‑Raf (human): S729‑p, B‑Raf (mouse): S766‑p, B‑Raf iso3 (mouse): ‑, B‑Raf (rat): S766‑p, B‑Raf (chicken): S769‑p, B‑Raf (quail): S769‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site
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Disease tissue studied:
adrenal cancer, pheochromocytoma
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Relevant cell lines - cell types - tissues:
oocyte, PC-12 (chromaffin)
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Cellular systems studied:
cell lines, primary cells
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Species studied:
frog, rat
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Downstream Regulation
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Effect of modification (function):
enzymatic activity, induced, molecular association, regulation
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Effect of modification (process):
cell differentiation, altered
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Modification regulates interactions with:
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Interacting molecule
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Interacting domains
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Effect
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Consequences (function)
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Consequences (process)
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Detection assays
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14-3-3 beta (human)
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Induces
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|
|
pull-down assay, yeast two-hybrid
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