Curated Information
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Curated Information Page
PubMed Id: 11331870 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Chen R, et al. (2001) Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. Nat Cell Biol 3, 439-44 11331870
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y40-p - Etk (human)
Orthologous residues
Etk (human): Y40‑p, Etk (mouse): Y40‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), CHO (fibroblast) [EphB1 (human), transfection], HUVEC (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  hamster, human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
fibronectin increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, intracellular localization, molecular association, regulation
 Effect of modification (process):  cell motility, altered, cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FAK (human) FERM_N Induces molecular association, regulation cytoskeletal reorganization, cell motility, altered co-immunoprecipitation

Y397-p - FAK (human)
Orthologous residues
FAK (human): Y397‑p, FAK iso2 (human): Y216‑p, FAK iso5 (human): Y397‑p, FAK (mouse): Y428‑p, FAK iso3 (mouse): Y397‑p, FAK iso4 (mouse): Y397‑p, FAK (rat): Y397‑p, FAK (chicken): Y397‑p, FAK iso5 (chicken):
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), CHO (fibroblast) [EphB1 (human), transfection], HUVEC (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  hamster, human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, intracellular localization, molecular association, regulation
 Effect of modification (process):  cell motility, altered, cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FAK (human) FERM_N Induces molecular association, regulation cell motility, altered co-immunoprecipitation


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