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Orthologous residues
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cortactin (human): Y421‑p, cortactin iso3 (human): Y384‑p, cortactin (mouse): Y421‑p, cortactin (rat): Y383‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site, phospho-antibody
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Relevant cell lines - cell types - tissues:
293 (epithelial)
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Cellular systems studied:
cell lines
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Species studied:
human
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Upstream Regulation
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Treatments, proteins and their effect on site modification:
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Treatments
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Referenced Treatments
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Manipulated Protein
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Referenced Protein
|
Effect
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Notes
|
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SDF-1alpha
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|
|
|
increase
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|
|
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Downstream Regulation
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Effect of modification (process):
cell motility, altered, signaling pathway regulation
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Comments:
important for ligand-induced CXCR4 recycling and internalization, ERK1/2 activation, and chemotaxis
|
