Curated Information
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Curated Information Page
PubMed Id: 16905744 
Luo C, et al. (2006) CXCL12 induces tyrosine phosphorylation of cortactin, which plays a role in CXC chemokine receptor 4-mediated extracellular signal-regulated kinase activation and chemotaxis. J Biol Chem 281, 30081-93 16905744
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y383-p - Cortactin (rat)
Orthologous residues
Cortactin (human): Y421‑p, Cortactin iso2 (human): Y384‑p, Cortactin iso3 (human): Y384‑p, Cortactin (mouse): Y421‑p, Cortactin (rat): Y383‑p
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CXCL12 increase
Downstream Regulation
 Effect of modification (process):  cell motility, altered, signaling pathway regulation
 Comments:  important for ligand-induced CXCR4 recycling and internalization, ERK1/2 activation, and chemotaxis

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