Curated Information
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Curated Information Page
PubMed Id: 16912036 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Meyn MA, et al. (2006) Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity. J Biol Chem 281, 30907-16 16912036
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y70-p - Abl (human) ▲
Orthologous residues
Abl (human): Y70‑p, Abl iso2 (human): Y89‑p, Abl (mouse): Y70‑p, Abl iso2 (mouse): Y89‑p, Abl (rat): Y70‑p, Abl iso2 (rat): Y89‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  K562 (erythroid), Meg01 (megakaryoblast)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Fyn (human)
KINASE Lyn (human)
KINASE Hck (human)
Downstream Regulation
 Effect of modification (function):  activation
 Comments:  required for Bcr-Abl transforming activity

Y115-p - Abl (human) ▲
Orthologous residues
Abl (human): Y115‑p, Abl iso2 (human): Y134‑p, Abl (mouse): Y115‑p, Abl iso2 (mouse): Y134‑p, Abl (rat): Y115‑p, Abl iso2 (rat): Y134‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Lyn (human)
KINASE Fyn (human)
KINASE Hck (human)

Y128-p - Abl (human) ▲
Orthologous residues
Abl (human): Y128‑p, Abl iso2 (human): Y147‑p, Abl (mouse): Y128‑p, Abl iso2 (mouse): Y147‑p, Abl (rat): Y128‑p, Abl iso2 (rat): Y147‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Fyn (human)
KINASE Lyn (human)
KINASE Hck (human)

Y139-p - Abl (human) ▲
Orthologous residues
Abl (human): Y139‑p, Abl iso2 (human): Y158‑p, Abl (mouse): Y139‑p, Abl iso2 (mouse): Y158‑p, Abl (rat): Y139‑p, Abl iso2 (rat): Y158‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Fyn (human)
KINASE Lyn (human)
KINASE Hck (human)

Y172-p - Abl (human) ▲
Orthologous residues
Abl (human): Y172‑p, Abl iso2 (human): Y191‑p, Abl (mouse): Y172‑p, Abl iso2 (mouse): Y191‑p, Abl (rat): Y172‑p, Abl iso2 (rat): Y191‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Hck (human)
KINASE Lyn (human)
KINASE Fyn (human)

Y185-p - Abl (human) ▲
Orthologous residues
Abl (human): Y185‑p, Abl iso2 (human): Y204‑p, Abl (mouse): Y185‑p, Abl iso2 (mouse): Y204‑p, Abl (rat): Y185‑p, Abl iso2 (rat): Y204‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Hck (human)
KINASE Fyn (human)
KINASE Lyn (human)

Y215-p - Abl (human) ▲
Orthologous residues
Abl (human): Y215‑p, Abl iso2 (human): Y234‑p, Abl (mouse): Y215‑p, Abl iso2 (mouse): Y234‑p, Abl (rat): Y215‑p, Abl iso2 (rat): Y234‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Hck (human)
KINASE Lyn (human)
KINASE Fyn (human)

Y226-p - Abl (human) ▲
Orthologous residues
Abl (human): Y226‑p, Abl iso2 (human): Y245‑p, Abl (mouse): Y226‑p, Abl iso2 (mouse): Y245‑p, Abl (rat): Y226‑p, Abl iso2 (rat): Y245‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Fyn (human)
KINASE Lyn (human)
KINASE Hck (human)

Y393-p - Abl (human) ▲
Orthologous residues
Abl (human): Y393‑p, Abl iso2 (human): Y412‑p, Abl (mouse): Y393‑p, Abl iso2 (mouse): Y412‑p, Abl (rat): Y393‑p, Abl iso2 (rat): Y412‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Hck (human)
KINASE Fyn (human)
KINASE Lyn (human)
KINASE Abl (human)

Y177-p - Bcr (human) ▲
Orthologous residues
Bcr (human): Y177‑p, Bcr (mouse): Y178‑p, Bcr (rat): Y178‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Lyn (human)
KINASE Abl (human)
KINASE Fyn (human)
KINASE Hck (human)


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