Curated Information
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Curated Information Page
PubMed Id: 16935857 
Kramer HF, et al. (2006) AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle. J Biol Chem 281, 31478-85 16935857
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T308-p - Akt1 (mouse)
Orthologous residues
Akt1 (human): T308‑p, Akt1 (mouse): T308‑p, Akt1 (rat): T308‑p, Akt1 (fruit fly): T423‑p, Akt1 (cow): T308‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  'muscle, skeletal'
 Cellular systems studied:  tissue
 Species studied:  mouse

T172-p - AMPKA2 (mouse)
Orthologous residues
AMPKA2 (human): T172‑p, AMPKA2 (mouse): T172‑p, AMPKA2 (rat): T172‑p, AMPKA2 (pig): T172‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  'muscle, skeletal'
 Cellular systems studied:  tissue
 Species studied:  mouse

S324-p - AS160 (mouse)
Orthologous residues
AS160 (human): S318‑p, AS160 iso3 (human): , AS160 (mouse): S324‑p, AS160 iso2 (mouse): S324‑p, AS160 (rat): S326‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3-L1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse

S595-p - AS160 (mouse)
Orthologous residues
AS160 (human): S588‑p, AS160 iso3 (human): S100‑p, AS160 (mouse): S595‑p, AS160 iso2 (mouse): S595‑p, AS160 (rat): S597‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3-L1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse

T649-p - AS160 (mouse)
Orthologous residues
AS160 (human): T642‑p, AS160 iso3 (human): T154‑p, AS160 (mouse): T649‑p, AS160 iso2 (mouse): T649‑p, AS160 (rat): T651‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'muscle, skeletal', 3T3-L1 (fibroblast)
 Cellular systems studied:  cell lines, tissue
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (mouse) phospho-motif antibody
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
muscle contraction increase
Downstream Regulation
 Comments:  important for insulin-stimulated glucose uptake

S758-p - AS160 (mouse)
Orthologous residues
AS160 (human): S751‑p, AS160 iso3 (human): S200‑p, AS160 (mouse): S758‑p, AS160 iso2 (mouse): S695‑p, AS160 (rat): S760‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3-L1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse


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