Curated Information
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Curated Information Page
PubMed Id: 9819383 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Bai RY, et al. (1998) Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity. Mol Cell Biol 18, 6951-61 9819383
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Y1604-p - ALK (human)
Orthologous residues
ALK (human): Y1604‑p, ALK (mouse):
Characterization
 Methods used to characterize site in vivo 2D analysis, mutation of modification site, phospho-antibody, phosphopeptide mapping, western blotting
 Disease tissue studied:  lymphoma, anaplastic large cell lymphoma, non-Hodgkin's lymphoma
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor'), Karpas-299 (T lymphocyte), Rat1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
 Comments:  Transfection of the constitutively active tyrosine kinase NPM-ALK into Ba/F3 and Rat-1 cells leads to a transformed phenotype.
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell cycle regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PLCG1 (mouse) SH2 Induces activity, induced co-immunoprecipitation
 Comments:  The complex formation leads to the tyrosine phosphorylation and activation of PLC-gamma.


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