Curated Information
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Curated Information Page
PubMed Id: 8041791 
Bennett AM, et al. (1994) Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. Proc Natl Acad Sci U S A 91, 7335-9 8041791
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y546-p - SHP-2 (human)
Orthologous residues
SHP‑2 (human): Y546‑p, SHP‑2 iso2 (human): Y542‑p, SHP‑2 (mouse): Y546‑p, SHP‑2 (rat): Y546‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, phosphoamino acid analysis, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], AT1009, ATWT
 Cellular systems studied:  cell lines
 Species studied:  dog
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PDGFRB (mouse)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Grb2 (mouse) Induces molecular association, regulation co-immunoprecipitation, electrophoretic visualization
 Comments:  Following PDGF stimulation, Grb2 binds tyrosine-phosphorylated SHPTP2


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