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Orthologous residues
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TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso5 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
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Characterization
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Methods used to characterize site in vivo:
phospho-antibody
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Relevant cell lines - cell types - tissues:
'neuron, ventral tegmental'-brain
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Cellular systems studied:
tissue
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Species studied:
rat
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Upstream Regulation
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Treatments, proteins and their effect on site modification:
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Treatments
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Referenced Treatments
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Manipulated Protein
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Referenced Protein
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Effect
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Notes
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leptin
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increase
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While there appears to be some increase in phospho-S40 after leptin infusion, there is an even larger increase in the total amount of TH in these leptin-treated mice, making a strong conclusion difficult.
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