Curated Information
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Curated Information Page
PubMed Id: 11290735 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Aicher LD, Campbell JS, Yeung RS (2001) Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis. J Biol Chem 276, 21017-21 11290735
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Y1573-p - TSC2 (rat)
Orthologous residues
TSC2 (human): Y1571‑p, TSC2 iso3 (human): Y1527‑p, TSC2 iso4 (human): Y1548‑p, TSC2 (mouse): Y1572‑p, TSC2 iso6 (mouse): Y1550‑p, TSC2 (rat): Y1573‑p, TSC2 iso2 (rat): Y1530‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, electrophoretic mobility shift, mutation of modification site, phospho-antibody, phosphoamino acid analysis, western blotting
 Disease tissue studied:  kidney cancer
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), COS (fibroblast), HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey, mouse
 Comments:  LEF8 (renal cancer cell line)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vanadate increase
serum increase
Downstream Regulation
 Effect of modification (function):  activity, induced, molecular association, regulation
 Effect of modification (process):  cell growth, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
TSC1 (rat) Induces co-immunoprecipitation


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