Curated Information

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Curated Information Page

PubMed Id: 16901786

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Zhang D, Zaugg K, Mak TW, Elledge SJ (2006) A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell 126, 529-42 16901786

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S67-p - USP28 (human)

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Orthologous residues

USP28 (human): S67‑p, USP28 (mouse): S67‑p

Characterization

Methods used to characterize site in vivo: mass spectrometry, phospho-antibody

Disease tissue studied: lung cancer, non-small cell lung cancer

Relevant cell lines - cell types - tissues: NCI-H460 (pulmonary)

Cellular systems studied: cell lines

Species studied: human

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	ATM (human)	genetic knockout/knockin of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
ionizing radiation				increase

Downstream Regulation

Effect of modification (process): apoptosis, altered

S714-p - USP28 (human)

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