Curated Information
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Curated Information Page
PubMed Id: 16858728 
Liang X, et al. (2006) Quantification of change in phosphorylation of BCR-ABL kinase and its substrates in response to Imatinib treatment in human chronic myelogenous leukemia cells. Proteomics 6, 4554-64 16858728
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y393-p - Abl (human)
Orthologous residues
Abl (human): Y393‑p, Abl iso2 (human): Y412‑p, Abl (mouse): Y393‑p, Abl iso2 (mouse): Y412‑p, Abl (rat): Y393‑p, Abl iso2 (rat): Y412‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Mo7R10 (megakaryoblast)
 Cellular systems studied:  cell lines
 Species studied:  human

Y644-p - Bcr (human)
Orthologous residues
Bcr (human): Y644‑p, Bcr (mouse): Y643‑p, Bcr (rat): Y643‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Mo7R10 (megakaryoblast)
 Cellular systems studied:  cell lines
 Species studied:  human

Y299-p - Dok2 (human)
Orthologous residues
Dok2 (human): Y299‑p, Dok2 (mouse): Y304‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Mo7R10 (megakaryoblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
imatinib decrease

Y1135-p - SHIP-2 (human)
Orthologous residues
SHIP‑2 (human): Y1135‑p, SHIP‑2 (mouse): Y1136‑p, SHIP‑2 (rat): Y1136‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Mo7R10 (megakaryoblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
imatinib decrease


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