Curated Information
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Curated Information Page
PubMed Id: 16858728 
Liang X, et al. (2006) Quantification of change in phosphorylation of BCR-ABL kinase and its substrates in response to Imatinib treatment in human chronic myelogenous leukemia cells. Proteomics 6, 4554-64 16858728
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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Y393-p - Abl (human)
Orthologous residues
Abl (human): Y393‑p, Abl iso2 (human): Y412‑p, Abl (mouse): Y393‑p, Abl iso2 (mouse): Y412‑p, Abl (rat): Y393‑p, Abl iso2 (rat): Y412‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Mo7R10 (megakaryoblast)
 Cellular systems studied:  cell lines
 Species studied:  human

Y644-p - Bcr (human)
Orthologous residues
Bcr (human): Y644‑p, Bcr iso2 (human): Y644‑p, Bcr (mouse): Y643‑p, Bcr (rat): Y643‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Mo7R10 (megakaryoblast)
 Cellular systems studied:  cell lines
 Species studied:  human

Y299-p - DOK2 (human)
Orthologous residues
DOK2 (human): Y299‑p, DOK2 (mouse): Y304‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Mo7R10 (megakaryoblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
imatinib decrease

Y1135-p - SHIP-2 (human)
Orthologous residues
SHIP‑2 (human): Y1135‑p, SHIP‑2 iso2 (human): Y893‑p, SHIP‑2 (mouse): Y1136‑p, SHIP‑2 (rat): Y1136‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  Mo7R10 (megakaryoblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
imatinib decrease


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