Curated Information
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Curated Information Page
PubMed Id: 16814111 
Hao Q, Rutherford SA, Low B, Tang H (2006) Selective regulation of hydrogen peroxide signaling by receptor tyrosine phosphatase-alpha. Free Radic Biol Med 41, 302-10 16814111
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y789-p - PTPRA iso2 (human)
Orthologous residues
PTPRA (human): Y798‑p, PTPRA iso2 (human): Y789‑p, PTPRA (mouse): Y825‑p, PTPRA (rat): Y792‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), HUVEC (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 decrease

Y428-p - FAK (mouse)
Orthologous residues
FAK (human): Y397‑p, FAK iso2 (human): Y216‑p, FAK iso5 (human): Y397‑p, FAK (mouse): Y428‑p, FAK iso3 (mouse): Y397‑p, FAK iso4 (mouse): Y397‑p, FAK (rat): Y397‑p, FAK (chicken): Y397‑p, FAK iso5 (chicken):
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 no change compared to control
H2O2 PTPRA (mouse) no change compared to control homozygous knockout

Y414-p - P130Cas (mouse)
Orthologous residues
P130Cas (human): Y410‑p, P130Cas iso7 (human): Y428‑p, P130Cas iso8 (human): Y410‑p, P130Cas (mouse): Y414‑p, P130Cas (rat): Y508‑p, P130Cas iso2 (rat): Y414‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 decrease
H2O2 PTPRA (mouse) inhibit treatment-induced decrease homozygous knockout

S657-p - PKCA (mouse)
Orthologous residues
PKCA (human): S657‑p, PKCA (mouse): S657‑p, PKCA (rat): S657‑p, PKCA (cow): S657‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 no change compared to control
H2O2 PTPRA (mouse) no change compared to control homozygous knockout

S744-p - PKD1 (mouse)
Orthologous residues
PKD1 (human): S738‑p, PKD1 (mouse): S744‑p, PKD1 (rat): S744‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 increase
H2O2 PTPRA (mouse) inhibit treatment-induced increase homozygous knockout
thrombin increase
thrombin PTPRA (mouse) no effect upon treatment-induced increase homozygous knockout
phorbol ester increase
phorbol ester PTPRA (mouse) no effect upon treatment-induced increase homozygous knockout

S748-p - PKD1 (mouse)
Orthologous residues
PKD1 (human): S742‑p, PKD1 (mouse): S748‑p, PKD1 (rat): S748‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 increase
H2O2 PTPRA (mouse) inhibit treatment-induced increase homozygous knockout
thrombin increase
thrombin PTPRA (mouse) no effect upon treatment-induced increase homozygous knockout
phorbol ester increase
phorbol ester PTPRA (mouse) no effect upon treatment-induced increase homozygous knockout

S916-p - PKD1 (mouse)
Orthologous residues
PKD1 (human): S910‑p, PKD1 (mouse): S916‑p, PKD1 (rat): S916‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 increase
H2O2 PTPRA (mouse) inhibit treatment-induced increase homozygous knockout

Y118-p - PXN (mouse)
Orthologous residues
PXN (human): Y118‑p, PXN iso2 (human): Y118‑p, PXN iso3 (human): Y118‑p, PXN iso6 (human): Y125‑p, PXN (mouse): Y118‑p, PXN iso2 (mouse): Y118‑p, PXN (rat): Y118‑p, PXN (chicken): Y118‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 decrease
H2O2 PTPRA (mouse) inhibit treatment-induced decrease homozygous knockout

Y424-p - Src (mouse)
Orthologous residues
Src (human): Y419‑p, Src (mouse): Y424‑p, Src iso2 (mouse): Y418‑p, Src (rat): Y419‑p, Src (chicken): Y416‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 decrease
H2O2 PTPRA (mouse) no effect upon treatment-induced decrease homozygous knockout


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