Curated Information
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Curated Information Page
PubMed Id: 9053848 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
de Jong R, ten Hoeve J, Heisterkamp N, Groffen J (1997) Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site. Oncogene 14, 507-13 9053848
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Y207-p - CrkL (human)
Orthologous residues
CrkL (human): Y207‑p, CrkL (mouse): Y207‑p, CrkL (rat): Y207‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Bcr/Abl (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Bcr/Abl (human) transfection of wild-type enzyme
Downstream Regulation
 Comments:  Phosphorylation of Y207 does not affect binding of signaling proteins to CRKL.


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