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Orthologous residues
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CrkL (human): Y207‑p, CrkL (mouse): Y207‑p, CrkL (rat): Y207‑p
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Characterization
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Methods used to characterize site in vivo:
electrophoretic mobility shift, mutation of modification site, phospho-antibody, western blotting
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Relevant cell lines - cell types - tissues:
3T3 (fibroblast), COS (fibroblast)
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Cellular systems studied:
cell lines
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Species studied:
monkey, mouse
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Enzymes shown to modify site in vitro:
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Upstream Regulation
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Potential in vivo enzymes for site:
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Type
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Enzyme
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Evidence
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Notes
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KINASE
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Bcr/Abl (human)
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transfection of wild-type enzyme
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Downstream Regulation
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Comments:
Phosphorylation of Y207 does not affect binding of signaling proteins to CRKL.
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