Curated Information
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Curated Information Page
PubMed Id: 16782881 
Garat CV, et al. (2006) Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells. Mol Cell Biol 26, 4934-48 16782881
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S117-p - CREB (rat)
Orthologous residues
CREB (human): S117‑p, CREB iso2 (human): S103‑p, CREB (mouse): S117‑p, CREB (rat): S117‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  'muscle, smooth'-pulmonary artery
 Cellular systems studied:  primary cultured cells
 Species studied:  rat
Downstream Regulation
 Effect of modification (function):  protein degradation
 Comments:  required for PDGF-induced protein ubiquitination

S121-p - CREB (rat)
Orthologous residues
CREB (human): S121‑p, CREB iso2 (human): S107‑p, CREB (mouse): S121‑p, CREB (rat): S121‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  'muscle, smooth'-pulmonary artery
 Cellular systems studied:  primary cultured cells
 Species studied:  rat
Downstream Regulation
 Effect of modification (function):  protein degradation
 Comments:  required for PDGF-induced protein ubiquitination


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