Curated Information

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Curated Information Page

PubMed Id: 9642287

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Hashimoto Y, et al. (1998) Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor. J Biol Chem 273, 17186-91 9642287

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y221-p - Crk (human)

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Orthologous residues

Crk (human): Y221‑p, Crk iso2 (human): ‑, Crk (mouse): Y221‑p, Crk (rat): Y221‑p, Crk (chicken): Y222‑p

Y221-p - Crk (rat)

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Orthologous residues

Crk (human): Y221‑p, Crk iso2 (human): ‑, Crk (mouse): Y221‑p, Crk (rat): Y221‑p, Crk (chicken): Y222‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: 293T (epithelial), NRK (fibroblast), P13

Cellular systems studied: cell lines

Species studied: human, mouse, rat

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	EGFR (human)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
EGF				increase

Downstream Regulation

Effect of modification (function): molecular association, regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
EGFR (human)		Disrupts	not reported		co-immunoprecipitation

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