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Orthologous residues
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|
TIF1B (human): S824‑p, TIF1B (mouse): S824‑p, TIF1B (rat): S825‑p
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|
Characterization
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|
Methods used to characterize site in vivo:
mutation of modification site, phospho-antibody
|
|
Relevant cell lines - cell types - tissues:
293 (epithelial)
|
|
Cellular systems studied:
cell lines
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|
Species studied:
human
|
|
Comments:
sensitivity to neocarzinostatin (NCS) of S824A mutant is increased
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
ATM (human)
|
activation of upstream enzyme
|
|
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
UV
|
|
|
|
increase
|
|
|
MMS
|
|
|
|
increase
|
|
|
hydroxyurea
|
|
|
|
increase
|
|
|
ionizing radiation
|
|
|
|
increase
|
|
|
|
Downstream Regulation
|
|
Effect of modification (process):
chromatin organization, altered
|
|
Comments:
constitutive phosphorylation of this site leads to permanent relaxation of chromatin
|
