Curated Information
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Curated Information Page
PubMed Id: 16862143 
Ziv Y, et al. (2006) Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat Cell Biol 8, 870-6 16862143
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S824-p - TIF1B (human)
Orthologous residues
TIF1B (human): S824‑p, TIF1B (mouse): S824‑p, TIF1B (rat): S825‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  sensitivity to neocarzinostatin (NCS) of S824A mutant is increased
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
UV increase
MMS increase
hydroxyurea increase
ionizing radiation increase
Downstream Regulation
 Effect of modification (process):  chromatin organization, altered
 Comments:  constitutive phosphorylation of this site leads to permanent relaxation of chromatin


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