Curated Information
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Curated Information Page
PubMed Id: 16809767 
Yue J, Ferrell JE (2006) Mechanistic studies of the mitotic activation of Mos. Mol Cell Biol 26, 5300-9 16809767
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S3-p - Mos (frog)
Orthologous residues
Mos (human): S3‑p, Mos (mouse): S50‑p, Mos (rat): S3‑p, Mos (frog): S3‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mass spectrometry, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  oocyte [CPEB (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  frog
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Comments:  necessary for oocyte maturation and the spindle assembly checkpoint

S16-p - Mos (frog)
Orthologous residues
Mos (human): S16‑p, Mos (mouse): S63‑p, Mos (rat): S16‑p, Mos (frog): S16‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  oocyte [CPEB (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  frog

S25-p - Mos (frog)
Orthologous residues
Mos (human): S25‑p, Mos (mouse): S72‑p, Mos (rat): S25‑p, Mos (frog): S25‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  oocyte [CPEB (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  frog

S26-p - Mos (frog)
Orthologous residues
Mos (human): S26‑p, Mos (mouse): I73‑p, Mos (rat): S26‑p, Mos (frog): S26‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  oocyte [CPEB (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  frog

S105-p - Mos (frog)
Orthologous residues
Mos (human): S102‑p, Mos (mouse): S152‑p, Mos (rat): N103‑p, Mos (frog): S105‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, phospho-antibody
 Relevant cell lines - cell types - tissues:  oocyte [CPEB (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  frog
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited
 Comments:  dephosphorylation of S105 is necessary for the mitotic activation of Mos


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