Curated Information
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Curated Information Page
PubMed Id: 16847063 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Anderson JP, et al. (2006) Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease. J Biol Chem 281, 29739-52 16847063
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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K12-ub - SNCA (human)
Orthologous residues
SNCA (human): K12‑ub, SNCA (mouse): K12‑ub, SNCA (rat): K12‑ub
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain
 Cellular systems studied:  tissue
 Species studied:  human

K21-ub - SNCA (human)
Orthologous residues
SNCA (human): K21‑ub, SNCA (mouse): K21‑ub, SNCA (rat): K21‑ub
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain
 Cellular systems studied:  tissue
 Species studied:  human

K23-ub - SNCA (human)
Orthologous residues
SNCA (human): K23‑ub, SNCA (mouse): K23‑ub, SNCA (rat): K23‑ub
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain
 Cellular systems studied:  tissue
 Species studied:  human

S129-p - SNCA (human)
Orthologous residues
SNCA (human): S129‑p, SNCA (mouse): S129‑p, SNCA (rat): S129‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, phospho-antibody
 Disease tissue studied:  synucleinopathy
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
synucleinopathy increased


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