Curated Information

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Curated Information Page

PubMed Id: 7781602

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Chan AC, et al. (1995) Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J 14, 2499-508 7781602

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y492-p - ZAP70 (human)

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Orthologous residues

ZAP70 (human): Y492‑p, ZAP70 (mouse): Y491‑p, ZAP70 (rat): Y487‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, mutation of modification site, peptide sequencing, phosphoamino acid analysis, phosphopeptide mapping

Disease tissue studied: lymphoma, B cell lymphoma

Relevant cell lines - cell types - tissues: DT40 (B lymphocyte), Jurkat (T lymphocyte), SF9

Cellular systems studied: cell lines

Species studied: chicken, human, insect

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	Lck (human)	modification site within consensus motif, phosphopeptide analysis, genetic transfer of wild-type enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
anti-TCR				increase

Y493-p - ZAP70 (human)

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