Curated Information

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Curated Information Page

PubMed Id: 16757566

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

McGettrick AF, et al. (2006) Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling. Proc Natl Acad Sci U S A 103, 9196-201 16757566

S16-p - TICAM2 (human)

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Orthologous residues

TICAM2 (human): S16‑p, TICAM2 (mouse): S14‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: THP1 (myeloid)

Cellular systems studied: cell lines

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PKCE (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	PKCE (human)	genetic knockout/knockin of upstream enzyme, pharmacological inhibitor of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
LPS				increase
bisindolylmaleimide	LPS			inhibit treatment-induced increase

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