Curated Information
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Curated Information Page
PubMed Id: 16829026 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Mouton V, et al. (2007) Evaluation of the role of protein kinase Czeta in insulin-induced heart 6-phosphofructo-2-kinase activation. Cell Signal 19, 52-61 16829026
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S473-p - Akt1 (rat) ▲
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  heart
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

T410-p - PKCZ (rat) ▲
Orthologous residues
PKCZ (human): T410‑p, PKCZ (mouse): T410‑p, PKCZ (rat): T410‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  heart
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

S467-p - PFKFB2 (cow) ▲
Orthologous residues
PFKFB2 (human): S466‑p, PFKFB2 iso2 (human): ‑, PFKFB2 (mouse): S469‑p, PFKFB2 iso3 (mouse): S468‑p, PFKFB2 (rat): S469‑p, PFKFB2 (cow): S467‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Akt1 (human)

T476-p - PFKFB2 (cow) ▲
Orthologous residues
PFKFB2 (human): T475‑p, PFKFB2 iso2 (human): ‑, PFKFB2 (mouse): T478‑p, PFKFB2 iso3 (mouse): T477‑p, PFKFB2 (rat): T478‑p, PFKFB2 (cow): T476‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE PKCZ (human)

S484-p - PFKFB2 (cow) ▲
Orthologous residues
PFKFB2 (human): S483‑p, PFKFB2 iso2 (human): ‑, PFKFB2 (mouse): S486‑p, PFKFB2 iso3 (mouse): S485‑p, PFKFB2 (rat): S486‑p, PFKFB2 (cow): S484‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Akt1 (human)


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