Curated Information

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Curated Information Page

PubMed Id: 10037717

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Di Bartolo V, et al. (1999) Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling. J Biol Chem 274, 6285-94 10037717

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y315-p - ZAP70 (human)

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Orthologous residues

ZAP70 (human): Y315‑p, ZAP70 (mouse): Y314‑p, ZAP70 (rat): Y310‑p

Characterization

Methods used to characterize site in vivo: 2D analysis, [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, phospho-antibody, phosphopeptide mapping, western blotting

Relevant cell lines - cell types - tissues: Jurkat (T lymphocyte)

Cellular systems studied: cell lines

Species studied: human, mouse

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	ZAP70 (human)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
anti-CD3				increase

Y319-p - ZAP70 (human)

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