Curated Information

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Curated Information Page

PubMed Id: 16420481

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Manceau V, et al. (2006) Major phosphorylation of SF1 on adjacent Ser-Pro motifs enhances interaction with U2AF65. FEBS J 273, 577-87 16420481

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S80-p - SF1 (human)

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Orthologous residues

SF1 (human): S80‑p, SF1 iso4 (human): S80‑p, SF1 iso5 (human): S205‑p, SF1 iso6 (human): S80‑p, SF1 (mouse): S80‑p, SF1 iso2 (mouse): S80‑p, SF1 (rat): S80‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, mutation of modification site, phosphopeptide mapping

Relevant cell lines - cell types - tissues: 293 (epithelial), WEHI-231 (B lymphocyte)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	KIS (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	KIS (human)	transfection of inactive enzyme

Downstream Regulation

Effect of modification (function): molecular association, regulation

Effect of modification (process): RNA splicing, altered

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
U2AF2 (human)		Induces		RNA splicing, altered	co-immunoprecipitation

Comments: facilitates formation of the SF1-U2AF-RNA complex

S82-p - SF1 (human)

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