Curated Information
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Curated Information Page
PubMed Id: 10820208 
Lindgren N, et al. (2000) Regulation of tyrosine hydroxylase activity and phosphorylation at Ser(19) and Ser(40) via activation of glutamate NMDA receptors in rat striatum. J Neurochem 74, 2470-7 10820208
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S19-p - TH (rat)
Orthologous residues
TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain
 Cellular systems studied:  primary cells
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
okadaic acid increase
forskolin no change compared to control
APV no change compared to control
NMDA increase
APV NMDA inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

S40-p - TH (rat)
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain
 Cellular systems studied:  primary cells
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NMDA decrease
forskolin increase
NMDA forskolin inhibit treatment-induced increase
cAMP analog increase
NMDA cAMP analog inhibit treatment-induced increase
okadaic acid increase
NMDA okadaic acid inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced


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