Curated Information
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Curated Information Page
PubMed Id: 8702790 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Gauzzi MC, et al. (1996) Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. J Biol Chem 271, 20494-500 8702790
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y1054-p - Tyk2 (human) ▲
Orthologous residues
Tyk2 (human): Y1054‑p, Tyk2 (mouse): Y1047‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  U1A (fibroblast) [Tyk2 (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Tyk2 (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IFN-alpha IFNAR1 (human) increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

Y1055-p - Tyk2 (human) ▲
Orthologous residues
Tyk2 (human): Y1055‑p, Tyk2 (mouse): Y1048‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  U1A (fibroblast) [Tyk2 (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Tyk2 (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IFN-alpha IFNAR1 (human) increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced


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